Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection
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چکیده
منابع مشابه
Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy.
Systemically administered oncolytic viruses have the ability to cause tumor destruction through the expansion and coalescence of intratumoral infectious centers. Efficacy is therefore dependent upon both the density and intratumoral distribution of virus-infected cells achieved after initial virus infusion, and delivery methods are being developed to enhance these critical parameters. However, ...
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ژورنال
عنوان ژورنال: Molecular Therapy - Oncolytics
سال: 2019
ISSN: 2372-7705
DOI: 10.1016/j.omto.2019.10.002